TY -的A2 -曹,红包AU - Rudko,奥尔加。非盟- Tretiakov Artemii诉AU - Naumova,埃琳娜·a . AU -克里莫夫,尤金·a . PY - 2020 DA - 2020/11/30 TI - PPARs在进展中的作用的焦虑:文献分析和信号通路重建SP - 8859017六世- 2020 AB -过氧物酶体proliferator-activated受体(PPAR)组包括三个亚型编码由PPARG PPARA, PPARD基因。高浓度的PPARs中发现部分与焦虑有关的大脑的开发,包括海马和杏仁核。在三个PPAR亚型,PPARG演示了最高的表达在中枢神经系统,它可以在神经元,星形胶质细胞和神经胶质细胞。,最高PPARG表达发生在杏仁核。然而,所知甚少考虑PPARs和焦虑行为之间存在的可能联系。我们回顾了PPARs和焦虑之间可能的联系。我们使用了通路工作室软件(爱思唯尔)。根据之前开发的算法创建信号通路。SNEA在执行路径工作室。目前的研究显示14 PPAR-regulated蛋白质与焦虑有关。 Possible mechanism of PPAR involvement in neuroinflammation protection is proposed. Signal pathway reconstruction and reviewing aimed to reveal possible connection between PPARG and CCK-ergic system was conducted. Said analysis revealed that PPARG-dependent regulation of MME and ACE peptidase expression may affect levels of nonhydrolysed, i.e., active CCK-4. Impairments in PPARG regulation and following MME and ACE peptidase expression impairments in amygdala may be the possible mechanism leading to pathological anxiety development, with brain CCK-4 accumulation being a key link. Literature data analysis and signal pathway reconstruction and reviewing revealed two possible mechanisms of peroxisome proliferator-activated receptors involvement in pathological anxiety: (1) cytokine expression and neuroinflammation mechanism and (2) regulation of peptidases targeted to anxiety-associated neuropeptides, primarily CCK-4, mechanism. SN - 1687-4757 UR - https://doi.org/10.1155/2020/8859017 DO - 10.1155/2020/8859017 JF - PPAR Research PB - Hindawi KW - ER -