TY - JOUR A2 - Madeo, Graziella AU - Orayj, Khalid AU - Lane, Emma PY - 2019 DA - 2019/11/03 TI - Patterns and Determinants of Prescribing for Parkinson’s Disease: A Systematic Literature Review SP - 9237181 VL - 2019 AB - Since the discovery of levodopa (L-dopa) in 1967, the range of medications available to treat Parkinson’s disease has increased significantly and guidance on the use, efficacy, and safety of these medications has evolved. To assess levels of adherence to national prescribing guidelines and awareness of changes in the efficacy and safety data published in the profiles of medications for the treatment of PD, we have reviewed studies on patterns and determinants of prescribing PD medications conducted in the last 50 years (since the discovery of L-dopa). A systematic literature review was conducted using EMBASE (1967 to March, 2018), Ovid MEDLINE(R) ALL (1967 to March 16, 2018), PsycINFO (1967 to the 2n2018年3月的一周),并识别衡量1967年至2017年间PD药物的所有研究的所有研究。研究设计,数据来源,学习源,患者年份和/或处方数,分析单位,分析单位,分析单位,分析单位,分析单位,分析单位在可能的情况下,提取了Cathtinant和Pd药物的利用率。44研究了在审查17个国家的处方模式和/或处方决定簇的研究。不出所料,L-DOPA是所有研究中最常见的药物,占PD所有处方的46.50%至100%。在几项研究中,Ergot衍生的多巴胺激动剂(DAS)的处方率随着指导的指导而随着时间的推移而减少。相比之下,在大多数内容研究中,非麦角DAS的规定率在过去十年中增加。在检查规定因素时,患有两大类,患者的因素和处方者的因素,患者年龄是影响大多数研究中处方的最常见因素。总之,L-DOPA现在是PD病例最常见的药物,但是,儿茶酚-O-甲基转移酶(COMT)抑制剂的规定率大变化,单胺氧化酶B(MAO-B)抑制剂,氨基胺和国家之间的抗胆碱能器。需要进行新的研究,审查最近的临床试验和测量新批准的药物的处方率的影响。 SN - 2090-8083 UR - https://doi.org/10.1155/2019/9237181 DO - 10.1155/2019/9237181 JF - Parkinson’s Disease PB - Hindawi KW - ER -