TY - JOUR A2 - Teive, Hélio AU - Camargo Maluf, Fauze AU - Feder, David AU - Alves de Siqueira Carvalho, Alzira PY - 2019 DA - 2019/11/23 TI - Analysis of the Relationship between Type II Diabetes Mellitus and Parkinson’s Disease: A Systematic Review SP - 4951379 VL - 2019 AB - In the early sixties, a discussion started regarding the association between Parkinson’s disease (PD) and type II diabetes mellitus (T2DM). Today, this potential relationship is still a matter of debate. This review aims to analyze both diseases concerning causal relationships and treatments. A total of 104 articles were found, and studies on animal and “in vitro” models showed that T2DM causes neurological alterations that may be associated with PD, such as deregulation of the dopaminergic system, a decrease in the expression of peroxisome proliferator-activated receptor-gamma coactivator-1 α.（ PGC-1α.），富含糖尿病/磷蛋白的磷蛋白表达的增加，富含星形胶质细胞15（PED / PEA-15）和神经炎症，以及α-突触核蛋白淀粉样蛋白原纤维的形成。此外，临床研究描述了在T2DM发作后帕金森的症状显着差，在T2DM和PD患者的DNA中鉴定了七种寄生基因。关于治疗，抗糖尿病药物，尤其是Incetin模拟剂的作用似乎赋予PD患者一定程度的神经保护。总之，有关T2DM和PD之间相互作用的可用证据证明了更强大的临床试验，探讨了这种相互作用的尤其是患者患者的临床管理。SN - 2090-8083 UR - https：//doi.org/10.1155/2019/4951379 do - 10.1155 / 2019/4951379 jf - 帕金森病pb - hindawikw - er -