TY - JOUR A2 - Vincenzo, Di Lazzaro AU - Heidari, Mohammad Hassan AU - Amini, Abdollah AU - Bahrami, Zohreh AU - Shahriari, Ali AU - Movafag, Abolfazle AU - Heidari, Reihane PY - 2013 DA - 2013/11/28TI - Effect of Chronic Morphine Consumption on Synaptic Plasticity of Rat’s Hippocampus: A Transmission Electron Microscopy Study SP - 290414 VL - 2013 AB - It is well known that the synapses undergo some changes in the brain during the course of normal life and under certain pathological or experimental circumstances. One of the main goals of numerous researchers has been to find the reasons for these structural changes. In the present study, we investigated the effects of chronic morphine consumption on synaptic plasticity, postsynaptic density thickness, and synaptic curvatures of hippocampus CA1 area of rats. So for reaching these goals, 24 n- 雄性大鼠被随机分为三组吗啡（吗啡（ n = 8 ）， 安慰剂 （ n = 8 ）和控制（ n = 8 ）组。在吗啡组中，使用吗啡（0.1、0.2、0.3和0.4）mg/ml的复合物以及安慰剂（蔗糖）组的蔗糖络合物（％0.3），使用了21天。药物治疗结束后，对动物进行了疤痕和灌注心脏的灌注，最后采集CA1海马样品进行超微结构研究，然后通过SPSS和单向方差分析获得的数据。我们的数据表明每NM的突触数³与其他两组相比，吗啡组的变化显着变化（安慰剂和对照）（ p < 0.001 ）以及统计分析显示，在突触后密度厚度方面，组之间存在显着差异（ p < 0.001 ）和突触曲率（ p < 0.007 ）。似乎大鼠的吗啡依赖性在海马的超微结构变化中起主要作用。SN -2090-1852 UR -https：//doi.org/10.1155/2013/290414 DO -10.1155/2013/2013/290414 JF-神经学研究国际PB -Hindawi Publisting Corporation KW -ER- ER-