TY - JOUR A2 - Dozio欧叶、赵丽欧苏、李汉欧吴、金明欧杨、李宝仁欧李、陈宝珠欧陈、黄宝达欧谢、黄俊杰欧王德宜、欧叶雪菊、欧宋玲、Ming-Tsan PY - 2020 DA - 2020/11/10 TI -谷氨酰胺的影响管理辅助T细胞调控和炎症反应在肥胖小鼠脓毒症复杂与幼童腹壁薄弱SP - 8869017六世- 2020 AB -本研究调查的影响GLN的炎症和T细胞失调肥胖老鼠与脓毒症复杂。小鼠分为正常对照组(NC)和高脂饮食组。高脂肪饮食提供60%的能量来自脂肪，并连续10周诱导肥胖。高脂肪饲料喂养的小鼠被分配到假手术组(SH)和败血症组(SS)或GLN组(SG)。SH组行剖腹手术，脓毒症组行盲肠结扎穿刺(CLP)。SS组静脉注射生理盐水。SG组在CLP后静脉滴注GLN。分别于clp后12、24、48 h处死小鼠。结果表明，在存在肥胖的情况下，败血症促使CD4+ T细胞向辅助性T (Th)2和Th17谱系靠拢。 Also, expressions of inflammatory cytokines and macrophage infiltration markers in adipose tissues and lungs were elevated. Treatment of obese mice with GLN after sepsis reversed Th polarization and downregulated macrophage infiltration and inflammatory cytokine, whereas the tight junction-associated protein expression increased in the lungs. These findings suggest that the intravenous administration of GLN to obese mice after sepsis modulated a more balanced Th cell lineage, alleviated inflammation, and attenuated lung injury. SN - 0962-9351 UR - https://doi.org/10.1155/2020/8869017 DO - 10.1155/2020/8869017 JF - Mediators of Inflammation PB - Hindawi KW - ER -