TY - JOUR A2 - 卡帕索，拉斐尔AU - 宫，丁苯胶AU - 花王，Yanlei AU - 张，张成林AU - 太阳，杨福东AU - 宫，朝华AU - 陈，建PY - 2020 DA - 2020年4月9日TI -5934821 VL - - 2020 AB - 集线器相关基因癌变和预后的大肠癌基于集成生物信息学SP的鉴定结肠直肠癌（CRC）的高死亡率的患者和常规肿瘤 - 淋巴结 - 转移的限制（TNM）阶段强调探索枢纽基因的必要性密切相关，在CRC癌变和预后。该研究的目的是确定与肿瘤的发生和预后相关联的CRC毂基因。我们从六个基因表达综合（GEO）数据集和癌症基因组图谱（TCGA）数据库中识别和验证的212个差异表达基因（DEGS）。我们调查了功能富集分析度的视角。的蛋白 - 蛋白相互作用（PPI）网络构建，并提取在CRC癌变集线器模块和基因。预后信号的开发和基于Cox比例风险回归分析验证。的主要DEGS调节生物过程覆盖响应于刺激，代谢过程，影响含蛋白质结合和催化活性分子的功能。该度的视角在癌前病变，癌变，转移，预后差，涉及CRC相关途径发挥了重要作用。 Hub genes closely related to CRC carcinogenesis were extracted including six genes in model 1 (CXCL1, CXCL3, CXCL8, CXCL11, NMU, and PPBP) and two genes and Metallothioneins (MTs) in model 2 (SLC26A3 and SLC30A10). Among them, CXCL8 was also related to prognosis. An eight-gene signature was proposed comprising AMH, WBSCR28, SFTA2, MYH2, POU4F1, SIX4, PGPEP1L, and PAX5. The study identified hub genes in CRC carcinogenesis and proposed an eight-gene signature with good reproducibility and robustness at the molecular level for CRC, which might provide directive significance for treatment selection and survival prediction. SN - 0962-9351 UR - https://doi.org/10.1155/2020/5934821 DO - 10.1155/2020/5934821 JF - Mediators of Inflammation PB - Hindawi KW - ER -