TY - JOUR A2 - Gladue, Ronald AU - de Jesus Oliveira, Flora Magno AU - Gonçalves-de-Albuquerque, Cassiano Felippe AU - de Moraes, Isabel Matos Medeiros AU - Reis, Patrícia Alves AU - Rocha, Vinicius Novaes AU - Bozza, Patrícia Torres AU - Silva, Adriana Ribeiro AU - de Castro Faria Neto, Hugo Caire PY - 2020 DA - 2020/10/14 TI - Simvastatin Posttreatment Controls Inflammation and Improves Bacterial Clearance in Experimental Sepsis SP - 1839762 VL - 2020 AB - Sepsis is characterized by a life-threatening organ dysfunction caused by an unbalanced host response to microbe infection that can lead to death.败血症除了目前是全世界特护单元死亡的主因外,还可能在幸存者中诱发长期后果,如认知缺陷。statins(悬浮低耗药广泛用于治疗dislipidema)显示拥有胸膜反炎和抗微生物效果3-HIG-CoA阻抗卷积酶-HMG-CoA-Co这项工作中,我们评估simvastein在动物败血模型中的治疗效果上组研究中 statin预处理避免认知损伤 神经发炎活塞集中研究急性炎症,败血症由剖析和穿孔诱导,动物外科后用仿冒素处理(2 mg/kg)6h等离子生物化学标记测得器官机能失常、细胞迁移、细胞激活、消除细菌、CLP24H后生成一氧化二氮、7天生存率和CLP15天后认知缺陷simvastatin6h单控后CLP能够预防肝脏和肾功能失常此外,该药还减少了腹部细胞积聚和TNF- α IMF、IL-6和IL-1 辰族 .Simvastatin减少细菌聚积单元数并增加腹膜一氧化二氮生产Simvastatin处理提高前24h生存率,但7天结束时没有改变生存率检测结果显示后处理Simvastatin抑制机能失常,增加本地氧化氮生产量,提高细菌清除量,并用相关败血模型调节炎症SN-0962-9351UR-https://doi.org/101155/20839762DO-10.1155/202018397662JF-InflamationPB-HindawiKW-ER-