TY -的A2 D 'Acquisto,,非盟- D 'Abramo亚历山德拉AU - Zingaropoli,玛丽亚·安东内拉·AU -奥利瓦·拉斯泰利亚历山德拉AU - D \ ' agostino博士克劳迪娅AU - Al Moghazi萨米尔AU - De Luca会非盟- Iannetta Marco AU - Mastroianni克劳迪奥·玛丽亚盟——Vullo Vincenzo PY - 2014 DA - 2014/10/14 TI -免疫激活,免疫衰老,Osteoprotegerin标记内皮功能障碍的亚临床艾滋病动脉粥样硬化SP - 192594六世- 2014 AB -感染艾滋病毒的患者心血管疾病的风险大大提高。几个标记包括osteoprotegerin已被证明参与动脉粥样硬化的发展。osteoprotegerin,我们调查了t细胞表型之间的关系和动脉粥样硬化评价颈动脉内膜中层厚度(c-IMT) 94年HIV阳性患者抑制抗逆转录病毒疗法Framingham分数< 10%。至于对照组,24阴性的受试者参加。c-IMT被超声评估。CD4 + / CD8 + t细胞激活(CD38 + HLADR +)和衰老(CD57 + CD28−)通过流式细胞仪测定。通过酶联免疫试剂盒il - 6和功能水平测定。c-IMT HIV +的更高比控制。在HIV阳性患者中,44.7%有病理c-IMT(≥0.9毫米)。CD8 + t细胞活化功能、衰老和HIV阳性患者的血浆水平高于控制。 Subjects with pathological c-IMT exhibited higher CD8+ immune activation and immunosenescence and OPG levels than subjects with normal c-IMT. Multivariate analysis showed that age, CD8+ CD38+ HLADR+, and CD8+ CD28− CD57+ were independently associated with pathological c-IMT. Several factors have been implicated in the pathogenesis of atherosclerosis in HIV patients. Immune activation and immunosenescence of CD8+ T cell together with OPG plasma levels might be associated with the development and progression of early atherosclerosis, even in the case of viral suppression. SN - 0962-9351 UR - https://doi.org/10.1155/2014/192594 DO - 10.1155/2014/192594 JF - Mediators of Inflammation PB - Hindawi Publishing Corporation KW - ER -