TY - JOUR A2 - Parkinson, Gary AU - Wu, Gang AU - Kwan, Irene C. M. AU - Yan, Zhimin AU - Huang, Yining AU - Ye, Eric PY - 2017 DA - 2017/11/02 TI - On the Helical Structure of Guanosine 5′-Monophosphate Formed at pH 5: Is It Left- or Right-Handed? SP - 6798759 VL - 2017 AB - Early X-ray fiber diffraction studies have established that the spontaneous gel formation of guanosine 5′-monophosphate (5′-GMP) under slightly acidic conditions (e.g., pH 5) results from self-assembly of 5′-GMP into a helical structure in which hydrogen-bonded guanine bases form a continuous helix with 15 nucleotides per 4 turns. For more than five decades, the sense of this helix is believed to be left-handed. Using multinuclear solid-state NMR and IR spectroscopic methods, we have finally determined the long-missing structural details of this helix. First, we found that this 5′-GMP helix is right-handed containing exclusive C3′- endo.糖褶皱。其次，我们展示了这个螺旋的中央频道没有na⁺离子与在pH8的5'-gmp形成的螺旋形成鲜明对比的鲜明对比度鲜明对比。中央通道填充NA⁺离子。SN - 2090-0201 UR - https://doi.org/10.1155/2017/6798759 Do - 10.1155 / 2017/6798759 JF - 核酸Pb - Hindawi Kw - Er -