TY-JOURA2-Bush AshleyiiAU - Doméné, Aurélie AU - Cavanagh, Chelsea AU - Page, Guylène AU - Bodard, Sylvie AU - Klein, Christophe AU - Delarasse, Cécile AU - Chalon, Sylvie AU - Krantic, Slavica PY - 2016 DA - 2016/09/08 TI - Expression of Phenotypic Astrocyte Marker Is Increased in a Transgenic Mouse Model of Alzheimer's Disease versus Age-Matched Controls: A Presymptomatic Stage Study SP - 5696241 VL - 2016 AB - Recent mouse studies of the presymptomatic stage of Alzheimer's disease (AD) have suggested that proinflammatory changes, such as glial activation and cytokine induction, may occur already at this early stage through unknown mechanisms.因为TNF α 帮助提高A 辰族 自A制作 辰族 原型蛋白质,我们评估 APP/A 辰族 和TNF α 3个月的APPSWE/PS1dE9小鼠的河马Campus西方染色体显出APP表达式 辰族 无法检测Westblot或ELISA证明3个月的APPswe/PS1dE9小鼠处于AD相似病理预感阶段西方纹理还用于显示转基因小鼠GFAP提高表达式,与TNF均成正相关 α 和APP互为关联分光化学量化和函数激活标志显示APPswe/PS1dE9鼠标标识中GFAP模拟细胞有选择和显著增长微度形态变换 与天体作用相容 沿激活路径SN - 2090-8024UR- https://doi.org/101155/2016/5696241DO-10.1155/06/5696241JF-国际阿尔茨海默氏病期刊PB-Hindawi出版公司KW-ER-