TY - JOUR A2 - Fernandez-Martos, Carlos AU - Liu, Guo-Chen AU - Yan, Jun-Ping AU - He, Qing AU - An, Xin AU - Pan, Zhi-Zhong AU - Ding, Pei-Rong PY - 2016 DA - 2016/11/07 TI - Effect of Neoadjuvant Chemoradiotherapy with Capecitabine versus Fluorouracil for Locally Advanced Rectal Cancer: A Meta-Analysis SP - 1798285 VL - 2016 AB - A meta-analysis was carried out to compare the efficacy and safety of capecitabine plus radiation with 5-fluorouracil (5-FU) plus radiotherapy (RT) as neoadjuvant treatment in locally advanced rectal cancer (LARC).1998年1月至2014年10月,我们搜索Cochrane数据库、Ovid数据库、Medline数据库、Embase数据库、ISI数据库和中国生物医学文献数据库Capecitabine试验与5+RT比较被考虑列入LARCNEADjivant处理Revman软件用于分析这些数据九例测试都包含在这个元分析中,共覆盖314名病人元分析显示capecitabine集团在统计学上比pCR率高(OR,1.34!95%CI,1.10-1.64 P级 = 0.0 03 下调率95%CI,1.22-2.06 P级 = 0.0 007 下拉率95%CI,1.34-3.16 P级 = 0.0 01 距离偏移0.6395%CI,0.44-0.88 P级 = 0 . 007 并调低精子值(OR,0.2595%CI,0.11-0.54 P级 = 0.0 005 高发手脚综合症95%CI1.59-12.33 P级 = 0.0 04 )Capecitabine比5-FU效率更高,Neadjuft对LARC病人的肿瘤响应除HFS外优低毒性SN-1687-6121UR-https://doi.org/101155/2016/1798285DO-10.1155+16/1798285JF-Castroentrology研究实践PB-Hindawi出版公司KW-ER-