TY - JOUR A2 - Gonz lez L pez, Tom S. J. AU - Cittolin-Santos, G. F. AU - Khalil, S. AU - Bakos, J. K. AU - Baker, K. PY - 2020 DA - 2020/05/15 TI - Chronic Atrophic Gastritis with Negative Intrinsic Factor and Parietal Cell Antibody Presenting as a Severe Hemolytic Anemia SP - 8697493 VL - 2020 AB - A 28-year-old Caucasian male with Hashimoto’s disease and vitiligo presented with two weeks of dizziness on exertion following pharyngitis which was treated with prednisone 40 mg by mouth once a day for five days. Initial workup revealed anemia, elevated lactate dehydrogenase (LDH), and low haptoglobin. He underwent workup for causes of hemolytic anemia which was remarkable for a peripheral blood smear with hypersegmented neutrophils and low vitamin B12 levels concerning for pernicious anemia. Parietal cell and intrinsic factor antibodies were negative, and he then underwent an esophagogastroduodenoscopy with biopsy. The biopsy was negative for 幽门螺杆菌和免疫组化染色均提示萎缩性胃炎的。他每天B12 1000微克肌内注射开始对维生素。他的血红蛋白，LDH，并结合珠蛋白标准化。由于缺乏壁细胞抗体和内在因素的抗体，这是血清反应阴性的恶性贫血的罕见的情况。SN - 2090-6560 UR - https://doi.org/10.1155/2020/8697493 DO - 10.1155 /八百六十九万七千四百九十三分之二千○二十〇JF - 病例报告血液学PB - Hindawi出版KW - ER -