TY - JOUR TI - 异丙酚在大鼠VL的基底核影响GABA-A受体导致意识丧失 - 2020 PY - 2020 DA - 二〇二〇年二月二十〇日DO - 10.1155 /九百三十七万○八百九十一分之二千○二十零UR - https://doi.org/10.1155/2020/9370891 AB -目的。丙泊酚是一个经典的麻醉剂和诱导意识丧失，和γ-氨基酸 - 型-A（GABA-A）受体是它的目标。翻正反射与意识响应相关联。所述基底核（NB）充当网状激活系统和额叶皮质（FC）之间的主要中继。丙泊酚可能通过调解影响NB GABA-A受体翻正反射。方法。Fifty male SD rats (250-350 g) were divided into parts I and II. In part I, 20 male SD rats were randomly divided into control group (CG) and NB-lesion group (NG, ibotenic acid-induced NB lesion). In part II, 30 male SD rats were treated with saline (0.9% NaCl, SG group), muscimol (a GABA-A receptor agonist, MG group), and gabazine (a GABA-A receptor antagonist, GG group) in NB, respectively. Two weeks later, the activity of the rats was measured between CG and NG groups. The rats were intravenously injected with propofol (50 mg/kg/h) to test the time of loss of righting reflex (LORR) in all rats. When LORR occurred, the rats received single administration of propofol (12 mg/kg) to measure the time of return of righting reflex (RORR). Electroencephalogram (EEG) activity of the frontal cortex (FC) was recorded.结果。NB神经元数目是由44％NG组相比，减少了CG组（ ）而老鼠的活动是NG组中减少一点时与CG组相比，但统计学差异不显着（ ）。丙泊酚的剂量 - 响应曲线向左偏移了NG组中，而对于LORR的时间的统计差异在两组之间不显着（ ）。然而，RORR和FCΔ功率的时间的NG组与CG组相比增加（ ）。在部分II中，MG组相比，SG组时，同时反向结果的GG组中观察到（RORR和FC粉末的时间增加 ）。有三组间的LORR和ED50的时间内没有显著影响（ ）。 结论。单侧病变NB增加了恢复时间和FC三角洲功率和NB区域可能参与了丙泊酚给药后出现。丙泊酚效力于通过影响NB GABA-A受体引起意识丧失至关重要的作用。JF - 行为神经学SN - 0953-4180 PB - Hindawi出版SP - 9370891 KW - A2 - Tambasco，尼古拉AU - 兴，云龙AU - 隶，楷AU - 娇，袁非盟 - 李，ER淄楠 -