TY - JOUR A2 - 吉夫托保罗斯，Kostis AU - 阿昌庞，德斯蒙德O. AU - Barffour，艾萨克K. AU - 柏叶，亚历克斯AU - Asiamah，欧内斯特A. AU - Armah，弗朗西斯A. AU - Adokoh，基督教K. AU -奥卢耶米·乔伊F. AU - Adrah，本杰明AU - 奥波库，理查德AU - Adakudugu，灵光PY - 2019 DA - 2019年9月25日TI - 从精油的Histoprotective影响柑橘aurantifolia睾酮诱导良性前列腺增生症大鼠SP - 3031609 VL - 2019 AB - 背景。良性前列腺增生（BPH）是老年男性中报道了常见的泌尿系统疾病。 目的。该研究评估了石灰精油（LEO）的histoprotective影响睾酮诱导良性前列腺增生（BPH）的大鼠模型和评估其对睾丸，肾脏和肝脏反向睾酮介导的变化的能力。 材料和方法。Adult Sprague Dawley (aged 12 weeks, 240–390 g) male rats were intramuscularly injected with testosterone enanthate (TE) (10 mg/kg) reconstituted in olive oil for ten days to establish benign prostatic hyperplasia (serum PSA level ≥ 1.24 ng/ml) in. After confirmation of BPH (sustained serum PSA level ≥ 1.24 ng/ml), rats in all groups (LEO: 30, 100, and 300 mg/kg, PO， ñ = 6; finasteride: 15 mg/kg, PO， ñ = 6) except model (BPH without treatment) and sham (no BPH and no treatment) groups were treated for 21 days. At the end of treatment, rats were anesthetised and blood was collected via cardiac puncture to determine serum PSA and total antioxidant capacity (TAC) levels. The prostate gland, testis, kidney, and liver were harvested, weighed, histologically processed and stained with H&E. 结果。LEO-和非那雄胺治疗组记录较小的平均前列腺权重相对他们的模型组。基线平均血清PSA LEO-和非那雄胺处理组的水平显著降低（ p < 0.05 ）相对于模型组。血清TAC水平LEO-和相对于模型组非那雄胺治疗组也更高。LEO治疗组具有较少的增厚腺上皮，更小的腺泡，更少前列腺分泌物和相对于模型组更纤维肌性基质。LEO和非那雄胺处理制得改进的睾丸，肾组织形态学特征和肝相比模型组。 结论。通过目前的结果， 柑橘aurantifoliaLEO可能拥有可以被探索针对BPH转化医学活性剂。SN - 1687-6369 UR - https://doi.org/10.1155/2019/3031609 DO - 10.1155 /三百○三万一千六百○九分之二千○一十九JF - Hindawi出版KW - - 泌尿外科PB进展ER -