TY-JOURA2-MatutesEstellaMAU - Abreu, Maria AU - Miranda, Marta AU - Castro, Mafalda AU - Fernandes, Iolanda AU - Cabral, Renata AU - Santos, Ana Helena AU - Fonseca, Sónia AU - Rodrigues, João AU - Leander, Magdalena AU - Lau, Catarina AU - Freitas, Inês AU - Coimbra, Susana AU - Santos-Silva, Alice AU - Lima, Margarida PY - 2021 DA - 2021/07/21 TI - IL-31 and IL-8 in Cutaneous T-Cell Lymphoma: Looking for Their Role in Itch SP - 5582581 VL - 2021 AB - The itch associated with cutaneous T-cell lymphoma (CTCL), including Mycosis Fungoides (MF) and Sézary syndrome (SS), is often severe and poorly responsive to treatment with antihistamines.最近的研究突显了跨语言在非histamigicITch中可能发挥的作用我们调查IL-31和IL-8在CTCL的作用,涉及疾病严重程度和相关痒27名CCTL病人的血清样本(17MF和10SS)和29控件(捐血者)被分析评估了与疾病和痒严重程度的关联性ITL-31血清水平高于控件水平,SS高于MF水平高病者血清IL-31水平高于先发性疾病者,并呈阳性关联性与白化脱水素和乙二微球素水平以及塞扎里细胞计数67%的CTCL病人受Ich影响(MF47%SS:100%)血清IL-31水平阻塞病人比控件和免痒病人高血清IL-8与疾病严重程度无关,或与痒有关srumIL-8水平与CCTL病人外围血清数和中子数成正相关研究显示IL-31与CTCL关联插件的作用, 特别是在高级疾病和SSs中, 提供新治疗方法的合理目标某些病人观察到血清增加IL-8可能与伴生感染相关联,它通过征集中子分量和推动释放中子分量加深痒的作用值得进一步调查SN-1687-9104UR-https://doi.org/101155021/5581DO-10.11550201/5581JF-HemdawiKW-ER